Description
Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.
Episodes
- 2026 / 9 / 18Hugging Face Co-Founder on Open-Source, Microduck, and NVIDIA | E2339This Week In Startups is made possible by: Superhuman: http://superhuman.com/ Paypal: http://paypal.launch.co Odoo: http://Odoo.com/twist Plaud: http://Plaud.ai/twist Harmonic: http://harmonic.ai/ Today’s...
- 2026 / 9 / 1590% of AI prototypes never reach production (w/ Temporal's Samar Abbas) | AI BasicsThe TWiST AI Basics series is made possible by Google for Startups! Build context-aware AI workflows using DeepMind models and orchestration tools with Google for Startups' new Startup technical guide on...
- 2026 / 9 / 14Ask Jason: AI Extinction, Grok's Rogue Meme Coin & Weed Farms as Data Centers | E2337This Week In Startups is made possible by: Quo: http://quo.com/TWiST The Conservation Fund: https://conservationfund.org CLA: ...
- 2026 / 9 / 11The Pentagon Wants Equity in AI Startups | E2336This Week In Startups is made possible by: DigitalOcean — Want to see what building on a true AI-native platform looks like? Head to do.co/twist to start building on DigitalOcean's AI-Native Cloud today —...
- 2026 / 9 / 10Becki DeGraw on founder vesting, advisor equity & the 4-term-sheet playThis Week In Startups is made possible by: Wilson Sonsini: https://www.wsgr.com/en/ Today's show: One of YouTube's three co-founders left for grad school and walked away with a fraction of what his...
- 2026 / 9 / 9Did OpenAI Steal the Navier-Stokes Solution? | E2335This Week In Startups is made possible by: Northwest Registered Agent -Â https://www.northwestregisteredagent.com/twistdomain NetSuite -Â https://www.netsuite.ai/twist Vanta...
- 2026 / 9 / 4Dr. Mark Hyman on Function Health & GLP-1 microdosing | E2334This Week In Startups is made possible by: Odoo - http://Odoo.com/twist Northwest Registered Agent - https://www.northwestregisteredagent.com/twistdomain Rippling - http://Rippling.ai/twist Today's show:...
- 2026 / 9 / 3Becki DeGraw on spinouts, IP licensing & clean exits | Wilson Sonsini Startup Legal BasicsThis Week In Startups is made possible by: Wilson Sonsini Today's show: Spinouts are everywhere right now, and most founders get the cap table wrong. Jason sits down with Becki DeGraw, partner at Wilson...
- 2026 / 9 / 2VC experts on why Physical AI funding is heating up | E2333VC experts on why Physical AI funding is heating up | E2333 This Week In Startups is made possible by: partner 1 - link partner 2 - link partner 3 - link Today's show: Are we one step closer to data centers...
- 2026 / 8 / 31Are AI Agents forming "civilizations" or is this just a psy op? | 2332This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twistdomain CLA https://claconnect.com/withyou Rippling https://Rippling.ai/twist Today's show: ...
- 2026 / 8 / 28Breaking down Nvidia's Hugging Face and Poolside bets | E2331This Week In Startups is made possible by: DigitalOcean https://do.co/twist Every.io https://every.io PayPal https://paypal.launch.co Today's show: *Nvidia agreed to buy Hugging Face for $12.9 billion, just...
- 2026 / 8 / 26Bill Gates foresees massive AI job loss: these VCs disagree | E2330This Week In Startups is made possible by: Lightfield https://lightfield.app Northwest Registered Agent https://www.northwestregisteredagent.com/twistdomain Rippling https://Rippling.ai/twist Today's show:...
- 2026 / 8 / 25You Can't Fire a VC From Your Board: Here's Why | Wilson Sonsini Startup Legal BasicsToday's show: Can a founder actually fire a board member? Short answer: almost never. And the reason why may surprise a lot of founders. On this edition of Legal Basics, Wilson Sonsini partner Becki DeGraw...
- 2026 / 8 / 25China wants you to cheer for the robots taking your job | E2329This Week In Startups is made possible by: Odoo https://Odoo.com/twist Quo https://quo.com/TWiST Conservation Fund https://conservationfund.org how old a movie has to be for me to be able to show a part of it...
- 2026 / 8 / 21Open source is going to win it all: Harvey proves it | E2328This Week In Startups is made possible by: Superhuman https://Superhuman.com Sentry https://sentry.io/twist Lightfield https://lightfield.app Today's show: Jason's been saying it for years now (and we've...
- 2026 / 8 / 20Taste is the new programming language (w/ Astrocade CEO Amir Sadeghian) | AI BasicsThe TWiST AI Basics series is made possible by Google Cloud! Build context-aware AI workflows using DeepMind models and orchestration tools with Google for Startups' new Startup technical guide on generative...
- 2026 / 8 / 19Neurosymbolic AI outperforms chatbots and product search | E2327This Week In Startups is made possible by: Vanta https://www.vanta.com/twist Agree https://agree.com YSecurity https://YSecurity.io/TWIST Today's show: Frontier AI models can ace PhD-level exams, but it's...
- 2026 / 8 / 17Bittensor creator Const on Affine, dTAO, "mining reasoning," and more | E2326This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twist DigitalOcean https://do.co/twist Odoo https://Odoo.com/twist Today's show: We've been going...
- 2026 / 8 / 15What we'll learn from Anthropic's $2-$3T IPO | E2325This Week In Startups is made possible by: PayPal Open https://paypalopen.com CLA https://claconnect.com/withyou Odoo https://Odoo.com/twist Today's show: *Anthropic is likely headed for the largest IPO in...
- 2026 / 8 / 12These robots could cut delivery costs by 80% | Next UnicornsThese robots could cut delivery costs by 80% | Next Unicorns This Week In Startups is made possible by: Squarespace https://squarespace.com/twist Northwest Registered Agent...
- 2026 / 8 / 11Zuck's AI manifesto is a data center PR masterclass | E2323This Week In Startups is made possible by: Every.io https://every.io NetSuite https://NetSuite.ai/TWIST YSecurity https://YSecurity.io/TWIST Today's show: *Meta chief Mark Zuckerberg published a 6,500 word...
- 2026 / 8 / 7How AI splits startups into winners and losers | E2322This Week In Startups is made possible by: DigitalOcean https://do.co/twist Sentry https://sentry.io/twist Lightfield https://lightfield.app Today's show: A hedge fund just blew up shorting SaaS stocks. In...
- 2026 / 8 / 5Airtable's 80% off value crash: VCs explain why it's still a win | E2321This Week In Startups is made possible by: Vanta https://www.vanta.com/twist Agree https://agree.com Odoo https://Odoo.com/twist Today's show: *Airtable just sold for $2.25 billion, an 81% drop from its...
- 2026 / 8 / 3How Bespoke faked AI until it actually worked (w/ Akemi Tsunagawa) | E2320This Week In Startups is made possible by: Odoo https://Odoo.com/twist Quo https://quo.com/TWiST Northwest Registered Agent https://northwestregisteredagent.com/twist Today's show: *Before Bespoke's "travel...
- 2026 / 7 / 31Why AI has no taste and how to fix it (w/ Thais Castello Branco) | E2319This Week In Startups is made possible by: YSecurity https://YSecurity.io/TWIST MongoDB https://MongoDB.com/ai Odoo https://Odoo.com/twist Today's show: AI models can solve PhD-level math equations and code...
- 2026 / 7 / 29Banning Chinese robots isn't regulatory capture | E2318This Week In Startups is made possible by: Northwest Registered Agent- NorthwestRegisteredAgent.com/twist Odoo - Odoo.com/twist MongoDB - MongoDB.com/ai Today's show: The FCC's decision to ban Chinese...
- 2026 / 7 / 27While other cultivated meat companies are collapsing, this one turned a profit | E2317This Week In Startups is made possible by: Every.io https://every.io MongoDB https://MongoDB.com/ai Agree https://agree.com Today's show: *Most lab-grown meat companies have already gone under. It's...
- 2026 / 7 / 24Why quantum has been "10 years away" for 30 years | E2316This Week In Startups is made possible by: PayPal Open https://paypalopen.com DigitalOcean https://do.co/twist Rippling https://Rippling.ai/twist Today's show: *For three decades now, we've been told that...
- 2026 / 7 / 22Why this longevity startup raised in Japan, not Silicon Valley | TWiST Tokyo | E2315This Week In Startups is made possible by: Sentry https://sentry.io/twist Agree https://agree.com Northwest Registered Agent https://northwestregisteredagent.com/twist Today's show: French ex-martial artist...
- 2026 / 7 / 20The AI Securing Your Workforce Before a Mistake Ever Becomes a Breach | E2314This Week In Startups is made possible by: Vanta https://www.vanta.com/twist Superhuman https://superhuman.com YSecurity https://YSecurity.io/TWIST Today's show: *Cybersecurity has long focused on cleaning...
- 2026 / 7 / 20An AI that watches your every click may be the future of work | E2314This Week In Startups is made possible by: Vanta https://www.vanta.com/twist Superhuman https://superhuman.com YSecurity https://YSecurity.io/TWIST Today's show: *Cybersecurity has long focused on cleaning...
- 2026 / 7 / 17The dawn of surgery bots + buy a home for $250 (w/ Andromeda & Mogul) | E2313The dawn of surgery bots + buy a home for $250 (w/ Andromeda & Mogul) | E2313 This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twist CLA...
- 2026 / 7 / 15A Startup Is Trying to Buy PayPal… Craziest Deal of 2026! | E2312This Week In Startups is made possible by: MongoDB - MongoDB.com/ai Rippling - Rippling.ai/twist Agree.com - agree.com Today's show: Hustle Fund's Eric Bahn and Chapter One's Jeff Morris Jr. join our...
- 2026 / 7 / 13Jason turned $11 and one tweet into 1.1M views | E2311This Week In Startups is made possible by: Quo https://quo.com/TWiST PayPal Open https://paypalopen.com Northwest Registered Agent https://northwestregisteredagent.com/twist Today's show: *Jason spent $11...
- 2026 / 7 / 10Danny Bernstein left Big Tech to fund farm-bots | E2310This Week In Startups is made possible by: NetSuite https://NetSuite.ai/TWIST Squarespace https://squarespace.com/twist YSecurity https://YSecurity.io/TWIST Today's show: *America posted 400,000 farm jobs...
- 2026 / 7 / 8Why Data Is the Next $1 Trillion MarketThis Week In Startups is made possible by: Digital Ocean - do.co/twist Agree.com - agree.com Every.io - every.io. Today's show: How many startups matter in tech? Fewer than you think. That's why venture...
- 2026 / 7 / 6$100T is managed by "human duct tape" | E2308This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twist Vanta https://www.vanta.com/twist Sentry https://sentry.io/twist Today's show: *There are...
- 2026 / 7 / 6$100T is managed by “human duct tape” | E2308This Week In Startups is made possible by:Northwest Registered Agent https://northwestregisteredagent.com/twistVanta https://www.vanta.com/twistSentry https://sentry.io/twistToday’s show:*There are $100...
- 2026 / 7 / 1Why the VC Hype Cycle Always Gets It Wrong | VC Roundtable | E2307This Week In Startups is made possible by:CLA - www.claconnect.com/withyouNorthwest Registered Agent - www.northwestregisteredagent.com/twistAgree.com - www.agree.comToday’s show:Forget the...
- 2026 / 6 / 29Chamath on why young people need more agency, risk, and adventureThis Week In Startups is made possible by:Plaudhttps://Plaud.ai/twistShopifyhttps://shopify.com/twistLinkedIn Jobshttps://LinkedIn.com/twistNorthwest Registered...
- 2026 / 6 / 27Why F1 Teams are Replacing Wind Tunnels with Smart Tape | E2305This Week In Startups is made possible by:Plaud - https://Plaud.ai/twistSentry - https://sentry.io/twistNorthwest Registered Agent-https://northwestregisteredagent.com/twistDigitalOcean -...
- 2026 / 6 / 24Why the Future of Video Games is Moving Back to the Dinner TableThis Week In Startups is made possible by:Deel - deel.com/twistNorthwest Registered Agent - northwestregisteredagent.com/twistLinkedIn - linkedIn.com/twistToday’s show:Jason sits down with Brynn Putnam, CEO...
- 2026 / 6 / 22The hottest running app has nothing to do with speed | E2303This Week In Startups is made possible by:Agree - https://agree.comQuo - https://quo.com/TWiSTSuperhuman - https://superhuman.comToday’s show:In this double-header, Jason and Lon chat with Louis Phillips,...
- 2026 / 6 / 18Why SpaceX Buying Cursor Changes EverythingThis Week In Startups is made possible by:Deel - deel.com/twistLinkedIn - linkedIn.com/twistNorthwest Registered Agent - northwestregisteredagent.com/twistPlaud - https://Plaud.ai/twistToday’s show:Anthropic...
- 2026 / 6 / 15The Startup Building the First Hotel on the Moon…This Week In Startups is made possible by:Every.io - visit every.ioSentry.io - sentry.io/twistVanta - vanta.com/twistToday’s show:The next SpaceX won't be building rockets; it'll build the first hotel...
- 2026 / 6 / 13SpaceX IPO Day: What Wall St. and the media missed | E2300This Week In Startups is made possible by:Plaud https://Plaud.ai/twistPilot https://pilot.com/twistAgree https://agree.comIM8 Health https://IM8health.com/twistAfter watching Elon build out his rocket (and...
- 2026 / 6 / 10Why the most expensive Seed deals are the cheapest | E2299This Week In Startups is made possible by:NetSuite - Netsuite.com/TWiSTDeel - Deel.com/TWiSTSquarespace - Squarespace.com/TWiSTTwo days before SpaceX launches the largest IPO in history at a flat $135/share,...
- 2026 / 6 / 8The AI Tutor That Makes Kids Actually Think | E2298The AI Tutor That Makes Kids Actually Think | E2298This Week In Startups is made possible by:Northwest Registered Agent https://northwestregisteredagent.com/twistLinkedIn Jobs...
- 2026 / 6 / 6Anthropic wants to slow AI down and Bernie wants 50%: JCal Reacts | E2297This Week In Startups is made possible by:Grasshopper Bank https://grasshopper.bank/twistVanta https://www.vanta.com/twistRender https://render.com/twistPlaud https://Plaud.ai/twistToday’s show:Anthropic...
- 2026 / 6 / 3The Startup Turning Space Into a Logistics NetworkThis Week In Startups is made possible by:Northwest Registered Agent - NorthwestRegistereAagent.com/TWISTEvery - Every.ioSentry - Sentry.io/TWISTToday’s show:Want to get to space? Several launch companies can...