Description
Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.
Episodes
- 2026 / 11 / 12Running Google’s Gemma on Satlyt’s orbital AI (w/ CEO Rama Afullo)The TWiST AI Basics series is made possible by Google for Startups! Today’s show: Rama Afullo pitched orbital data centers while working at both Google and SpaceX. At the latter, he was told that the...
- 2026 / 11 / 12Founders Are Now Sending VCs a File Written for AIThis Week In Startups is made possible by: Odoo: https://Odoo.com/twist Superhuman: https://superhuman.com/ Stripe: https://stripe.com/startups Athena: https://www.athena.com/jcal Plaud:...
- 2026 / 11 / 10Can Nvidia Survive the Jensen Huang Spy Scandal? | E2361This Week In Startups is made possible by: Stripe: https://stripe.com/startups Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Upwork: https://www.upwork.com Plaud:...
- 2026 / 11 / 6Did the Midterms Destroy All Hope for Data Centers? | E2360This Week In Startups is made possible by: Odoo: https://Odoo.com/twist Sentry: https://sentry.io/twist Stripe: https://stripe.com/startups Plaud: https://Plaud.ai/twist Today’s show: Democrats swept...
- 2026 / 11 / 5Why a Do-Nothing Congress could be great for markets | E2359This Week In Startups is made possible by: Every: https://every.io/ Vanta: https://www.vanta.com/twist G2i: http://G2i.co/twist Plaud: https://Plaud.ai/twist Fintrx:...
- 2026 / 11 / 3Odyssey CEO Oliver Cameron is 90% sure we live in a simulation | E2358This Week In Startups is made possible by: Paper: https://getpaper.ai/twist G2i: https://G2i.co/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Plaud:...
- 2026 / 10 / 30Binance Hacked $6.3B Stolen, DoorDash Buys Instacart For $17B, Jake Newfield from Hermetiq, + More!This Week In Startups is made possible by: Stripe: https://stripe.com/startups Rippling: https://Rippling.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Plaud:...
- 2026 / 10 / 29Is AI the new cigarettes? Our VC panel digs into Anthropic’s S-1 | E2356This Week In Startups is made possible by: PayPal: https://paypal.com/business The Conservation Fund: https://www.conservationfund.org/ Hostinger: https://hostinger.com/twist Plaud:...
- 2026 / 10 / 26Pregame Your Launch Before Your App Exists (w/ Amanda Bradford) | E2355This Week In Startups is made possible by: Odoo: https://odoo.com/twist G2i: https://g2i.co/twist Rippling: https://rippling.ai/twist Plaud: https://plaud.ai/twist Today’s show: Amanda Bradford’s...
- 2026 / 10 / 24OpenAI’s $1.25T Raise, Starlink Mobile & Zuck’s Tax Deal | EP 2354This Week In Startups is made possible by: Plaud - https://plaud.ai/twist Sentry - https://sentry.io/twist Lightfield - https://lightfield.app Rippling - https://rippling.ai/twist Today’s show: Is...
- 2026 / 10 / 22We asked 3 VCs: would you invest in Elizabeth Holmes’ next startup? | E2353This Week In Startups is made possible by: DigitalOcean - Head to https://do.co/twist to start building on DigitalOcean's AI-Native Cloud today — and cut your AI workload costs by up to 50% Odoo: The...
- 2026 / 10 / 20Anthropic Gives Away 5% of Its Shares, Clone’s Muscle Robot, ElevenLabs Steals Podcaster's VoiceThis Week In Startups is made possible by: Plaud: https://plaud.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Vanta: https://www.vanta.com/twist Rippling:...
- 2026 / 10 / 17Flying Cars, OpenAI Spies, Why AI Isn’t Sticking (Superhuman CEO)This Week In Startups is made possible by: Lightfield: https://lightfield.app/ Every.io: https://every.io/. PayPal: https://paypal.com/business Plaud: https://Plaud.ai/twist GoDaddy:...
- 2026 / 10 / 14The Ex-DeepMind Researcher Taking On China’s Open Source AIThis Week In Startups is made possible by: Paper: getpaper.ai/twist Superhuman: https://superhuman.com/ Odoo: https://Odoo.com/twist Today’s show: Misha Laskin of Reflection AI joins Jason to explain...
- 2026 / 10 / 12The Gadget That's Better in Crowds Than Your Phone + Ring’s Founder Before Amazon Bought It | E2349This Week In Startups is made possible by: Plaud: https://Plaud.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain NetSuite: https://netsuite.ai/twist The...
- 2026 / 10 / 10Jason Reacts To Japanese Founder Pitches + Fireside Chat With Yuki ShiratoThis Week In Startups is made possible by: Lightfield: https://lightfield.app/ Rippling: https://Rippling.ai/twist Upwork: http://upwork.com Today’s show: AssetHub built an AI agent that recreates...
- 2026 / 10 / 8What VCs Really Think About Personal AI Agents | E2347This Week In Startups is made possible by: Plaud: http://Plaud.ai/twist Odoo: http://Odoo.com/twist Northwest Registered Agent: http://www.northwestregisteredagent.com/twistdomain Quo:...
- 2026 / 10 / 5Jason Mentors The Next Generation + Why AI Is Bad at Teaching (Aristotle Interview) | E2346This Week In Startups is made possible by: Vanta: https://www.vanta.com/twist DigitalOcean: https://do.co/twist Sentry: http://sentry.io/twist Plaud: http://Plaud.ai/twist Today’s show: The smarter AI...
- 2026 / 10 / 3Inside The Startup Building Uncensored AI (Abliteration AI) | EP 2345This Week In Startups is made possible by: Every.io: http://every.io/ Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Odoo: http://Odoo.com/twist Plaud:...
- 2026 / 9 / 30Justin Kan & Brian Chesky: The Rejections That Built Twitch and Airbnb | E2344This Week In Startups is made possible by: Plaud: http://Plaud.ai/twist CLA: https://claconnect.com/tech Sentry: http://sentry.io/twist Lightfield: http://sentry.io/twist Today’s show: Google once...
- 2026 / 9 / 28Jason’s Put a $5K Bounty on His Dream Chrome Extension | E2338This Week In Startups is made possible by: Every.io: http://every.io/ Northwest Registered Agent: www.northwestregisteredagent.com/twistdomain Sentry: http://sentry.io/twist Today’s show: A product that...
- 2026 / 9 / 28The 5 Companies Apple Must BuyThis Week In Startups is made possible by: PayPal - https://paypal.com/business Northwest Registered Agent - https://www.northwestregisteredagent.com/twistdomain Odoo - https://Odoo.com/twist Today’s...
- 2026 / 9 / 25A rogue OpenAI agent hacked Australia’s government. Does this matter? | E2342This Week In Startups is made possible by: https://lightfield.app/ http://getpaper.ai/twist https://conservationfund.org/ http://Plaud.ai/twist https://www.athena.com/jcal Today’s show: An OpenAI agent...
- 2026 / 9 / 23VCs Would Bet on Open-Source AI Over OpenAI and Anthropic | E2341This Week In Startups is made possible by: Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Odoo: http://Odoo.com/twist Rippling: http://Rippling.ai/twist Plaud:...
- 2026 / 9 / 21Elon's New Hyperloop, Trump's AI Rename, and a Model That Won't Talk | E2340This Week In Startups is made possible by: Vanta: https://www.vanta.com/twist DigitalOcean: http://do.co/twist Lightfield: https://lightfield.app/ Plaud: http://Plaud.ai/twist Today’s show: Elon...
- 2026 / 9 / 18Hugging Face Co-Founder on Open-Source, Microduck, and NVIDIA | E2339This Week In Startups is made possible by: Superhuman: http://superhuman.com/ Paypal: http://paypal.launch.co Odoo: http://Odoo.com/twist Plaud: http://Plaud.ai/twist Harmonic: http://harmonic.ai/ Today’s...
- 2026 / 9 / 1590% of AI prototypes never reach production (w/ Temporal's Samar Abbas) | AI BasicsThe TWiST AI Basics series is made possible by Google for Startups! Build context-aware AI workflows using DeepMind models and orchestration tools with Google for Startups' new Startup technical guide on...
- 2026 / 9 / 14Ask Jason: AI Extinction, Grok's Rogue Meme Coin & Weed Farms as Data Centers | E2337This Week In Startups is made possible by: Quo: http://quo.com/TWiST The Conservation Fund: https://conservationfund.org CLA: ...
- 2026 / 9 / 11The Pentagon Wants Equity in AI Startups | E2336This Week In Startups is made possible by: DigitalOcean — Want to see what building on a true AI-native platform looks like? Head to do.co/twist to start building on DigitalOcean's AI-Native Cloud today —...
- 2026 / 9 / 10Becki DeGraw on founder vesting, advisor equity & the 4-term-sheet playThis Week In Startups is made possible by: Wilson Sonsini: https://www.wsgr.com/en/ Today's show: One of YouTube's three co-founders left for grad school and walked away with a fraction of what his...
- 2026 / 9 / 9Did OpenAI Steal the Navier-Stokes Solution? | E2335This Week In Startups is made possible by: Northwest Registered Agent -Â https://www.northwestregisteredagent.com/twistdomain NetSuite -Â https://www.netsuite.ai/twist Vanta...
- 2026 / 9 / 4Dr. Mark Hyman on Function Health & GLP-1 microdosing | E2334This Week In Startups is made possible by: Odoo - http://Odoo.com/twist Northwest Registered Agent - https://www.northwestregisteredagent.com/twistdomain Rippling - http://Rippling.ai/twist Today's show:...
- 2026 / 9 / 3Becki DeGraw on spinouts, IP licensing & clean exits | Wilson Sonsini Startup Legal BasicsThis Week In Startups is made possible by: Wilson Sonsini Today's show: Spinouts are everywhere right now, and most founders get the cap table wrong. Jason sits down with Becki DeGraw, partner at Wilson...
- 2026 / 9 / 2VC experts on why Physical AI funding is heating up | E2333VC experts on why Physical AI funding is heating up | E2333 This Week In Startups is made possible by: partner 1 - link partner 2 - link partner 3 - link Today's show: Are we one step closer to data centers...
- 2026 / 8 / 31Are AI Agents forming "civilizations" or is this just a psy op? | 2332This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twistdomain CLA https://claconnect.com/withyou Rippling https://Rippling.ai/twist Today's show: ...
- 2026 / 8 / 28Breaking down Nvidia's Hugging Face and Poolside bets | E2331This Week In Startups is made possible by: DigitalOcean https://do.co/twist Every.io https://every.io PayPal https://paypal.launch.co Today's show: *Nvidia agreed to buy Hugging Face for $12.9 billion, just...
- 2026 / 8 / 26Bill Gates foresees massive AI job loss: these VCs disagree | E2330This Week In Startups is made possible by: Lightfield https://lightfield.app Northwest Registered Agent https://www.northwestregisteredagent.com/twistdomain Rippling https://Rippling.ai/twist Today's show:...
- 2026 / 8 / 25You Can't Fire a VC From Your Board: Here's Why | Wilson Sonsini Startup Legal BasicsToday's show: Can a founder actually fire a board member? Short answer: almost never. And the reason why may surprise a lot of founders. On this edition of Legal Basics, Wilson Sonsini partner Becki DeGraw...
- 2026 / 8 / 25China wants you to cheer for the robots taking your job | E2329This Week In Startups is made possible by: Odoo https://Odoo.com/twist Quo https://quo.com/TWiST Conservation Fund https://conservationfund.org how old a movie has to be for me to be able to show a part of it...
- 2026 / 8 / 21Open source is going to win it all: Harvey proves it | E2328This Week In Startups is made possible by: Superhuman https://Superhuman.com Sentry https://sentry.io/twist Lightfield https://lightfield.app Today's show: Jason's been saying it for years now (and we've...
- 2026 / 8 / 20Taste is the new programming language (w/ Astrocade CEO Amir Sadeghian) | AI BasicsThe TWiST AI Basics series is made possible by Google Cloud! Build context-aware AI workflows using DeepMind models and orchestration tools with Google for Startups' new Startup technical guide on generative...
- 2026 / 8 / 19Neurosymbolic AI outperforms chatbots and product search | E2327This Week In Startups is made possible by: Vanta https://www.vanta.com/twist Agree https://agree.com YSecurity https://YSecurity.io/TWIST Today's show: Frontier AI models can ace PhD-level exams, but it's...
- 2026 / 8 / 17Bittensor creator Const on Affine, dTAO, "mining reasoning," and more | E2326This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twist DigitalOcean https://do.co/twist Odoo https://Odoo.com/twist Today's show: We've been going...
- 2026 / 8 / 15What we'll learn from Anthropic's $2-$3T IPO | E2325This Week In Startups is made possible by: PayPal Open https://paypalopen.com CLA https://claconnect.com/withyou Odoo https://Odoo.com/twist Today's show: *Anthropic is likely headed for the largest IPO in...
- 2026 / 8 / 12These robots could cut delivery costs by 80% | Next UnicornsThese robots could cut delivery costs by 80% | Next Unicorns This Week In Startups is made possible by: Squarespace https://squarespace.com/twist Northwest Registered Agent...
- 2026 / 8 / 11Zuck's AI manifesto is a data center PR masterclass | E2323This Week In Startups is made possible by: Every.io https://every.io NetSuite https://NetSuite.ai/TWIST YSecurity https://YSecurity.io/TWIST Today's show: *Meta chief Mark Zuckerberg published a 6,500 word...
- 2026 / 8 / 7How AI splits startups into winners and losers | E2322This Week In Startups is made possible by: DigitalOcean https://do.co/twist Sentry https://sentry.io/twist Lightfield https://lightfield.app Today's show: A hedge fund just blew up shorting SaaS stocks. In...
- 2026 / 8 / 5Airtable's 80% off value crash: VCs explain why it's still a win | E2321This Week In Startups is made possible by: Vanta https://www.vanta.com/twist Agree https://agree.com Odoo https://Odoo.com/twist Today's show: *Airtable just sold for $2.25 billion, an 81% drop from its...
- 2026 / 8 / 3How Bespoke faked AI until it actually worked (w/ Akemi Tsunagawa) | E2320This Week In Startups is made possible by: Odoo https://Odoo.com/twist Quo https://quo.com/TWiST Northwest Registered Agent https://northwestregisteredagent.com/twist Today's show: *Before Bespoke's "travel...
- 2026 / 7 / 31Why AI has no taste and how to fix it (w/ Thais Castello Branco) | E2319This Week In Startups is made possible by: YSecurity https://YSecurity.io/TWIST MongoDB https://MongoDB.com/ai Odoo https://Odoo.com/twist Today's show: AI models can solve PhD-level math equations and code...